Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11491253 | 0.92 | XIAP (0.41) | LPAR1LPAR5XIAPMAPK14DPP4 | |
| SCHEMBL11486116 | 0.87 | LPAR1 (0.41) | LPAR1LPAR5XIAPMAPK14DPP4 | |
| SCHEMBL11489437 | 0.86 | LPAR1 (0.42) | LPAR1LPAR5MMP14 | |
| SCHEMBL11480234 | 0.85 | LTA4H (0.49) | MAPTLTA4H | |
| SCHEMBL11478588 | 0.84 | POLB (0.40) | LMNAL3MBTL1LTA4H | |
| SCHEMBL11479694 | 0.82 | MMP13 (0.38) | MAPTLTA4H | |
| SCHEMBL11486056 | 0.80 | HSPB1 (0.40) | LPAR1LPAR5MAPK14LMNAAR | |
| SCHEMBL11492460 | 0.79 | LTA4H (0.36) | LMNAMAPTTDP1LTA4H | |
| SCHEMBL11487583 | 0.79 | PARP10 (0.42) | LPAR1LPAR5MMP14 | |
| SCHEMBL11493229 | 0.78 | CYP2A6 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4196215-A | Alkyne compounds and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1980-04-01 | — | — | US | disclosed |
| US-4115456-A | Alkyne compounds and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1978-09-19 | — | — | US | disclosed |