Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11082691 | 0.82 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11086849 | 0.80 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| Hydrochloric Acid SCHEMBL9127458 | 0.79 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11474908 | 0.77 | ADRA1A (0.46) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| Hydrochloric Acid SCHEMBL11472518 | 0.77 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL11083181 | 0.75 | ADRB2 (0.71) | ADRA1AADRA1DADRA1BADRB2DRD2 | |
| SCHEMBL7317207 | 0.74 | ADRB2 (0.49) | ADRA1AADRA1DADRA1BADRB2DRD3 | |
| Cliropamine SCHEMBL2110690 | 0.74 | ADRB2 (0.49) | ADRA1AADRA1DADRA1BADRB2DRD3 | |
| SCHEMBL7381182 | 0.74 | SIGMAR1 (0.57) | ADRA1AADRA1DADRA1BADRB2DRD3 | |
| Cliropamine SCHEMBL31741642 | 0.74 | SIGMAR1 (0.50) | ADRA1AADRA1DADRA1BADRB2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4217305-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1980-08-12 | — | — | US | disclosed |