Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11488120 | 0.90 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11484356 | 0.86 | MEN1 (0.49) | KDM4ESMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11245310 | 0.85 | EEF2K (0.45) | KDM4ESMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11488645 | 0.84 | ALDH1A1 (0.57) | KDM4ESMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11083105 | 0.82 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL11486236 | 0.81 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL11486400 | 0.75 | ADORA1 (0.45) | KDM4ELMNAMEN1KMT2AHSD17B10 | |
| SCHEMBL11080468 | 0.74 | LMNA (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL11158118 | 0.74 | EEF2K (0.48) | KDM4ESMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL11167142 | 0.74 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4215123-A | Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | claimed |
| US-4215123-A | Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-29 | — | — | US | disclosed |