Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11495734 | 0.84 | MAPT (0.46) | KDM4EALDH1A1MAPTGAAL3MBTL1 | |
| SCHEMBL11486169 | 0.80 | MAOA (0.43) | MAOBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL11488220 | 0.76 | ANPEP (0.40) | DRD2MAOBALDH1A1 | |
| SCHEMBL11485963 | 0.76 | HTR1A (0.45) | MAOBKDM4EALDH1A1MAPTGAA | |
| SCHEMBL9145281 | 0.74 | PTK2 (0.37) | KDM4EMAPTLMNA | |
| SCHEMBL11495822 | 0.73 | KDM4E (0.47) | KDM4EALDH1A1MAPTGAALMNA | |
| SCHEMBL5959482 | 0.73 | PGR (0.52) | DRD2MAOBKDM4EALDH1A1MAPT | |
| SCHEMBL1029836 | 0.71 | KDM4E (0.67) | MAOBKDM4EMAPTGAATOP1 | |
| SCHEMBL29126288 | 0.71 | MAPT (0.66) | KDM4EALDH1A1MAPTL3MBTL1TOP1 | |
| SCHEMBL13021607 | 0.71 | MAOA (0.49) | DRD2MAOBKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4220778-A | ANTIARRHYTHMIC, ANTIMICROBIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY | G. D. SEARLE & CO. (US) | 1980-09-02 | — | — | US | disclosed |