Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492631 | 0.99 | DRD2 (0.46) | DRD2DRD3DRD4SIGMAR1KCNH2 | |
| SCHEMBL11496471 | 0.96 | FDPS (0.45) | DRD2DRD3DRD4SIGMAR1FDPS | |
| SCHEMBL11493582 | 0.90 | DRD2 (0.47) | DRD2DRD3DRD4SIGMAR1FDPS | |
| SCHEMBL11493895 | 0.87 | ICMT (0.41) | DRD2DRD3DRD4SIGMAR1ICMT | |
| SCHEMBL11494126 | 0.87 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL11496271 | 0.86 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL11489231 | 0.86 | ICMT (0.43) | KCNH2ICMTALBHPGD | |
| SCHEMBL11496329 | 0.85 | SIGMAR1 (0.50) | SIGMAR1HPGD | |
| SCHEMBL11492540 | 0.83 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL11489578 | 0.83 | ICMT (0.36) | FDPSICMTALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |