Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.55 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.55 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.55 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | TACR2 | P21452 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4812479 | 0.96 | ESR1 (0.55) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Hydrochloric Acid SCHEMBL4813332 | 0.96 | ESR1 (0.55) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL8656531 | 0.85 | HTR2A (0.59) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL3920201 | 0.85 | HTR2A (0.59) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL8659288 | 0.83 | KMT2A (0.64) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL4053581 | 0.83 | KMT2A (0.59) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL8659628 | 0.83 | KMT2A (0.53) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Bromide SCHEMBL8662470 | 0.83 | ADRA2A (0.52) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL5299310 | 0.83 | HTR2A (0.61) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL5305758 | 0.83 | HTR2A (0.61) | ESR1ADRA2AADORA3TACR2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4192581-A | Electrochromic display device | Dai Nippon Toryo Co, Ltd. (JP) | 1980-03-11 | — | — | US | disclosed |