Sugi Predict

Sugi Predict / Compounds / SCHEMBL11501928

SCHEMBL11501928

SCHEMBL11501928

CC(Cl)c1cccc(Cl)c1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 3/20 0.65
▸ CYP3A4 P08684 3/20 0.65
▸ PNMT P11086 2/20 0.65
▸ CYP2D6 P10635 1/20 0.65
▸ NFKB1 P19838 1/20 0.65
▸ LMNA P02545 4/20 0.63
▸ ALDH1A1 P00352 1/20 0.63
▸ GLA P06280 1/20 0.63
▸ IDO1 P14902 1/20 0.43
▸ TDO2 P48775 1/20 0.43
▸ TSHR P16473 6/20 0.41
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ P2RX7 Q99572 1/20 0.37
▸ ADRB2 P07550 1/20 0.36
▸ ADRB1 P08588 1/20 0.36
▸ CYP2A6 P11509 1/20 0.36
▸ HIF1A Q16665 3/20 0.36
▸ SLC6A2 P23975 2/20 0.36
▸ HTR2B P41595 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22801396 0.83 CYP1A2 (0.68) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL423182 0.83 CYP1A2 (0.68) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL13145152 0.80 ADRB2 (0.47) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL1588934 0.80 ADRB2 (0.47) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL1872442 0.80 CYP1A2 (0.58) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL10980261 0.79 CYP1A2 (0.63) CYP1A2CYP3A4PNMTCYP2D6NFKB1
Methylamine SCHEMBL6500291 0.79 PNMT (0.69) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL15302407 0.79 CYP1A2 (0.63) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL8207165 0.79 PNMT (1.00) CYP1A2CYP3A4PNMTCYP2D6NFKB1
SCHEMBL8428077 0.79 CYP1A2 (0.63) CYP1A2CYP3A4PNMTCYP2D6NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199620-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF RAPT THERAPEUTICS, INC. 2024-06-20 — — US disclosed
US-10604526-B2 Chemokine receptor modulators and uses thereof RAPT THERAPEUTICS, INC. (US) 2020-03-31 — — US disclosed
US-20190152978-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF RAPT THERAPEUTICS, INC. 2019-05-23 — — US disclosed
CN-109789146-A chemokine receptor modulators and uses thereof FLX生物公司 2019-05-21 — — CN disclosed
US-4156602-A 1-(1-Chloropropyl)-2,4,6-triisopropylbenzene and its use to control weeds PPG INDUSTRIES, INC. (US) 1979-05-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152978-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF CCR4, CCR1, CCR3 CYP1A2 3706/4885CYP3A4 1261/4885PNMT 2391/4885
US-10604526-B2 Chemokine receptor modulators and uses thereof CCR4, CCR1, CCR3 CYP1A2 3706/4885CYP3A4 1261/4885PNMT 2391/4885
US-20240199620-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF CCR4, CCR1, CCR3 CYP1A2 3706/4885CYP3A4 1261/4885PNMT 2391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.