Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588934 | 1.00 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL2865478 | 0.83 | GABRA1 (0.43) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL12204154 | 0.81 | ADRB2 (0.48) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL84509 | 0.81 | GABRA1 (0.50) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL11501928 | 0.80 | CYP1A2 (0.65) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL947512 | 0.78 | TSHR (0.50) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL11617245 | 0.78 | TSHR (0.50) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL30848757 | 0.78 | TSHR (0.50) | ADRB2ADRB1TSHRLMNAHIF1A | |
| 1,2-Dichlorobenzene SCHEMBL23407542 | 0.77 | TSHR (0.67) | ADRB2ADRB1TSHRLMNAHIF1A | |
| SCHEMBL17553340 | 0.77 | ADRB2 (0.46) | ADRB2ADRB1TSHRLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105523944-A | Synthetic method of 2-bromo-4-(2-chloro-ethyl)-aniline | UNIV CHANGZHOU | 2016-04-27 | — | — | CN | claimed |
| CN-109789146-A | chemokine receptor modulators and uses thereof | FLX生物公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109180418-A | A kind of propylene oxide co-production object resource utilization synthetic pesticide intermediate 2,4 dichloro benzene ethyl ketone method | 江苏扬农化工集团有限公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-103974950-B | Substituted benzimidazole and benzopyrazoles class as CCR (4) antagonist | 凯莫森特里克斯股份有限公司 | 2016-12-21 | — | — | CN | disclosed |
| US-9440992-B2 | 5,7-disubstituted thiazolo[4,5-D]pyrimidines as chemokine inhibitors | Acturum Life Science AB (SE) | 2016-09-13 | — | — | US | disclosed |
| CN-105523944-A | Synthetic method of 2-bromo-4-(2-chloro-ethyl)-aniline | UNIV CHANGZHOU | 2016-04-27 | — | — | CN | disclosed |
| US-8273890-B2 | Thiophene-imidazopyridines | 4SC AG (DE) | 2012-09-25 | — | — | US | disclosed |
| US-7947693-B2 | 2R)-2-[(2-amino-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]pentan-1-ol; neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases su COPD, asthma | ASTRAZENECA AB (SE) | 2011-05-24 | — | — | US | disclosed |
| US-20110092519-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES AS CHEMOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2011-04-21 | — | — | US | disclosed |
| CN-101193897-B | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives | ASTRAZENECA AB | 2010-12-01 | — | — | CN | disclosed |
| US-7799952-B2 | Stereoselective method for the production of (R)-Dimepranol | RATIOPHARM GMBH (DE) | 2010-09-21 | — | — | US | disclosed |
| US-20090149677-A1 | Stereoselective Method for the Production of (R)-Dimepranol | RATIOPHARM GMBH (DE) | 2009-06-11 | — | — | US | disclosed |
| US-7507827-B2 | Stereoselective method for the production of Clopidogrel | RATIOPHARM GMBH (DE) | 2009-03-24 | — | — | US | disclosed |
| EP-2017277-A1 | Thiophene-imidazopyridines | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2009003911-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2009-01-08 | — | — | WO | disclosed |
| US-20080214578-A1 | Novel 5-Substituted 7-Amino-[1,3]Thiazolo[4,5-D]Pyrimidine Derivatives 793 | ACTURUM REAL ESTATE AB (SE) | 2008-09-04 | — | — | US | disclosed |
| CN-101193897-A | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives | ASTRAZENECA AB (SE) | 2008-06-04 | — | — | CN | disclosed |
| US-20070219166-A1 | Stereoselective Method for the Production of Clopidogrel | RATIOPHARM GMBH (DE) | 2007-09-20 | — | — | US | disclosed |
| CN-1121426-C | Process for controlled radical polymerization or copolymerization of (meth) acrylic, vinyl, vinylidene and diene monomers, and (co) polymers obtained | ATOCHEM ELF SA (FR) | 2003-09-17 | — | — | CN | disclosed |
| CN-1186079-A | Process for controlled radical polymerization or copolymerization of (meth) acrylic, vinyl, vinylidene and diene monomers, and (co) polymers obtained | ATOCHEM ELF SA (FR) | 1998-07-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092519-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES AS CHEMOKINE INHIBITORS | CX3CR1, CCR2, CXCR3 | ADRB2 190/4885ADRB1 101/4885TSHR 577/4885 |
| US-20080214578-A1 | Novel 5-Substituted 7-Amino-[1,3]Thiazolo[4,5-D]Pyrimidine Derivatives 793 | CX3CR1, CCR2, CXCR3 | ADRB2 152/4885ADRB1 64/4885TSHR 481/4885 |
| US-20090149677-A1 | Stereoselective Method for the Production of (R)-Dimepranol | ADH5, ADH1A, ADH1C | ADRB2 124/4885ADRB1 69/4885TSHR 1515/4885 |
| US-20070219166-A1 | Stereoselective Method for the Production of Clopidogrel | CYP2C19, ADH1C, TBXA2R | ADRB2 82/4885ADRB1 32/4885TSHR 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.