Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801396 | 0.95 | CYP1A2 (0.68) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL8207165 | 0.82 | PNMT (1.00) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL158333 | 0.82 | PNMT (1.00) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL8207792 | 0.82 | PNMT (1.00) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL423182 | 0.81 | CYP1A2 (0.68) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| Hydrochloric Acid SCHEMBL1321451 | 0.80 | LMNA (1.00) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL11501928 | 0.79 | CYP1A2 (0.65) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL30051168 | 0.77 | CYP1A2 (0.52) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL1170186 | 0.77 | CYP1A2 (0.52) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL10980261 | 0.77 | CYP1A2 (0.63) | PNMTCYP1A2CYP3A4CYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924391-B2 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| US-20020037875-A1 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037875-A1 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors | PLA2G4B, PLA2G4A, PLA2G1B | PNMT 2136/4885CYP1A2 657/4885CYP3A4 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.