Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266115 | 0.82 | MAPT (0.52) | PIK3CDPIK3CAPIK3CGATRIDO1 | |
| SCHEMBL4251692 | 0.81 | BCHE (0.48) | ATRIDO1MAOBKMOKDM4E | |
| SCHEMBL11513041 | 0.78 | IDO1 (0.51) | PIK3CDPIK3CAPIK3CGATRIDO1 | |
| SCHEMBL15309634 | 0.78 | HSD17B1 (0.59) | PIK3CAPIK3CGATRKDM1ACYP3A4 | |
| SCHEMBL11468072 | 0.77 | KMO (0.58) | PIK3CDPIK3CAPIK3CGIDO1KDM1A | |
| SCHEMBL10650790 | 0.77 | CNR2 (0.50) | IDO1MAOBKDM1AKMOXDH | |
| SCHEMBL837257 | 0.76 | MAPT (0.53) | ATRKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5593110 | 0.75 | AGTR1 (0.68) | ATRIDO1KDM1AKMOXDH | |
| SCHEMBL15309782 | 0.74 | PRKDC (0.47) | ATRMAOBKDM1AADORA2AADORA1 | |
| SCHEMBL40313 | 0.73 | FEN1 (0.55) | PIK3CDPIK3CAPIK3CGATRIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159375-A | 6- AND 7-Aryl-1,2,4-triazolo[4,3-b]-1,2,4-triazines | AMERICAN CYANAMID COMPANY (US) | 1979-06-26 | — | — | US | disclosed |