SCHEMBL115114

SCHEMBL115114

CNc1ncc(C(F)(F)F)cc1N

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.43
ALDH1A1 P00352 5/20 0.42
GAA P10253 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
POLB P06746 4/20 0.40
KDM4E B2RXH2 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
PKM P14618 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NOS3 P29474 1/20 0.36
NOS2 P35228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29431605 1.00 CFTR (0.43) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL15426487 0.87 CFTR (0.36) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL10280736 0.86 CFTR (0.35) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL6985291 0.81 AGBL2 (0.45) ALDH1A1GAASMN1; SMN2POLBKDM4E
SCHEMBL15427225 0.81 SMN1; SMN2 (0.44) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL3827007 0.81 L3MBTL1 (0.43) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL26039496 0.79 SMN1; SMN2 (0.42) ALDH1A1GAASMN1; SMN2POLBKDM4E
SCHEMBL10281003 0.78 POLB (0.46) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL3449414 0.78 POLB (0.49) CFTRALDH1A1GAASMN1; SMN2POLB
SCHEMBL12600405 0.78 EGFR (0.45) CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3983411-B1 FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS PI INDUSTRIES LTD (IN) 2026-05-27 EP disclosed
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2026-04-16 US disclosed
EP-4724425-A1 SYNTHESIS OF ENANTIOENRICHED 2-CYANO PYRIDYL SULFOXIDES Syngenta Crop Protection AG (CH) 2026-04-15 EP disclosed
US-RE50663-E1 Heterocycle derivatives as pesticides BAYER AKTIENGESELLSCHAFT (DE) 2025-11-18 US disclosed
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-10-07 US disclosed
US-12384787-B2 Fused heterocyclic compounds and their use as pest control agents PI INDUSTRIES LTD (IN) 2025-08-12 US disclosed
US-20250230158-A1 CONDENSED BICYCLIC HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS BAYER AG (DE) 2025-07-17 US disclosed
EP-3802542-B1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFOXIMINE CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2025-05-28 EP disclosed
US-12297196-B2 Condensed bicyclic heterocyclic derivatives as pest control agents BAYER AKTIENGESELLSCHAFT (DE) 2025-05-13 US disclosed
WO-2025061707-A1 SYNTHESIS OF SULFOXIMINES CONTAINING A BENZIMIDAZOLE MOIETY SYNGENTA CROP PROTECTION AG (CH) 2025-03-27 WO disclosed
WO-2010125985-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-04 WO disclosed
EP-0676398-B1 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO CO (JP) 2001-10-24 EP disclosed
US-6117893-A Heterocyclic compounds having anti-diabetic activity and their use SANKYO COMPANY, LIMITED (JP) 2000-09-12 US disclosed
EP-1022274-A1 Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use Sankyo Company Limited (JP) 2000-07-26 EP disclosed
US-5977365-A HYPOGLYCEMIC AGENTS SANKYO COMPANY, LIMITED (JP) 1999-11-02 US disclosed
US-5962470-A Heterocyclic compounds having anti-diabetic activity and their use SANKYO COMPANY, LIMITED (JP) 1999-10-05 US disclosed
US-5834501-A TREATING DIABETES OR HYPERLIPEMIA SANKYO COMPANY, LIMITED (JP) 1998-11-10 US disclosed
US-5739345-A HYPOGLYCEMIC AND ANTIDIABETIC AGENTS SANKYO COMPANY, LIMITED (JP) 1998-04-14 US disclosed
US-5624935-A ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS SANKYO COMPANY, LIMITED 1997-04-29 US disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384787-B2 Fused heterocyclic compounds and their use as pest control agents DDT, ACHE, KEAP1 CFTR 2871/4885ALDH1A1 1353/4885GAA 500/4885
US-20250230158-A1 CONDENSED BICYCLIC HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS BCHE, C1R, C1S CFTR 3639/4885ALDH1A1 506/4885GAA 1504/4885
US-12435083-B2 Cyclopropyl-(hetero)aryl-substituted ethylsulphonyl-pyridine derivatives CYCS, CYP2E1, CYP1A1 CFTR 219/4885ALDH1A1 512/4885GAA 2196/4885
US-20260103464-A1 CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYL-PYRIDINE DERIVATIVES CBR3, CYCS, CBR1 CFTR 688/4885ALDH1A1 2267/4885GAA 4380/4885
US-12297196-B2 Condensed bicyclic heterocyclic derivatives as pest control agents BCHE, C1R, C1S CFTR 3639/4885ALDH1A1 506/4885GAA 1504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.