Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802603 | 0.87 | MPO (0.60) | MPOELANECYP3A4CYP11B2ABCB1 | |
| SCHEMBL14267917 | 0.83 | MPO (0.56) | MPOELANECYP3A4CYP11B2ABCB1 | |
| SCHEMBL23297253 | 0.83 | MPO (0.50) | MPOELANEEBPSIGMAR1MAPT | |
| SCHEMBL6858889 | 0.82 | MPO (0.57) | MPOELANECYP3A4EBPSIGMAR1 | |
| SCHEMBL114809 | 0.80 | EBP (0.65) | MPOEBPSIGMAR1ABCB1 | |
| SCHEMBL7633335 | 0.79 | MPO (0.51) | MPOELANECYP3A4CYP11B2ABCB1 | |
| SCHEMBL115122 | 0.78 | EBP (0.47) | MPOEBPSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8309725 | 0.77 | ESR1 (0.52) | MPOELANECYP3A4CYP11B2CYP17A1 | |
| SCHEMBL7633012 | 0.76 | MPO (0.54) | MPOELANEABCB1ALDH1A1MAPT | |
| SCHEMBL8310384 | 0.75 | BACE1 (0.49) | MPOELANECYP3A4CYP11B2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125578-A2 | A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE | GLENMARK GENERICS LIMITED (IN) | 2010-11-04 | — | — | WO | disclosed |