Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11520689 | 0.87 | TYK2 (0.42) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11524038 | 0.85 | RAB9A (0.41) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11524573 | 0.83 | RAB9A (0.46) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11519411 | 0.83 | RAB9A (0.47) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11521969 | 0.82 | JAK2 (0.42) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11522976 | 0.81 | RAB9A (0.45) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11526152 | 0.80 | RAB9A (0.42) | TYK2JAK2JAK1RAB9ANPC1 | |
| SCHEMBL11163699 | 0.78 | RAB9A (0.68) | RAB9ANPC1MAPT | |
| SCHEMBL11523665 | 0.78 | HCRTR1 (0.48) | TYK2RAB9ANPC1MAPTKDM4E | |
| SCHEMBL11525363 | 0.78 | CHEK1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |