Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11523665 | 0.88 | HCRTR1 (0.48) | RAB9ANPC1TYK2KDM4EMAPT | |
| SCHEMBL11524573 | 0.83 | RAB9A (0.46) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11519411 | 0.83 | RAB9A (0.47) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11520689 | 0.82 | TYK2 (0.42) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11525622 | 0.82 | RAB9A (0.44) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11522976 | 0.81 | RAB9A (0.45) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11519925 | 0.80 | TYK2 (0.46) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11522661 | 0.80 | IL2 (0.42) | RAB9ANPC1TYK2JAK2JAK1 | |
| SCHEMBL11163699 | 0.78 | RAB9A (0.68) | RAB9ANPC1MAPTALDH1A1NPSR1 | |
| SCHEMBL11604630 | 0.78 | RAB9A (0.48) | RAB9ANPC1TYK2JAK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |