Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 10/20 | 0.53 |
| ▸ | CA2 | P00918 | 10/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 7/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11520164 | 0.83 | MAPT (0.62) | MAPTCA1CA2CA12CA9 | |
| Potassium Ion SCHEMBL11516550 | 0.78 | CA1 (0.48) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL26502909 | 0.77 | MAPT (1.00) | MAPTCA1CA2CA12CA9 | |
| Potassium Ion SCHEMBL28546580 | 0.77 | CA1 (0.67) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL4277952 | 0.74 | MAPT (0.69) | MAPT | |
| SCHEMBL13767783 | 0.74 | MAPT (0.69) | MAPT | |
| SCHEMBL11517284 | 0.74 | MAPT (0.68) | MAPTCA2CA12CA9 | |
| SCHEMBL8389551 | 0.73 | CA1 (0.67) | MAPTCA1CA2CA12CA9 | |
| Potassium Ion SCHEMBL11594818 | 0.73 | CA1 (0.57) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL27468363 | 0.73 | CA1 (0.67) | MAPTCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4178301-A | 4-(2-(ACETYLTHIO)ACETAMIDO)BENZOIC ACID AS MUCOLYTIC AGENT | MEAD JOHNSON & COMPANY (US) | 1979-12-11 | — | — | US | disclosed |
| US-4132802-A | LIQUEFACTION OF MUCUS | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | disclosed |
| US-4096277-A | Mucolytic mercaptoacylamidobenzamides and process of using same | MEAD JOHNSON & COMPANY (US) | 1978-06-20 | — | — | US | disclosed |