Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11526796 | 0.84 | GAA (0.40) | BRD4ATMMARS1MEN1KMT2A | |
| SCHEMBL11526168 | 0.83 | MARS1 (0.52) | MARS1HTTSMPD1RPA1MAPT | |
| SCHEMBL11528510 | 0.82 | TRPM4 (0.38) | BRD4ATMMARS1MEN1KMT2A | |
| SCHEMBL11434769 | 0.69 | EPAS1 (0.38) | ATMMEN1KMT2ATRPM5TRPM4 | |
| SCHEMBL11662844 | 0.65 | LMNA (0.47) | BRD4TRPM5TRPM4LMNAPDE4A | |
| SCHEMBL17203549 | 0.65 | RPA1 (0.61) | MARS1MEN1KMT2AALOX12LMNA | |
| SCHEMBL11459539 | 0.65 | ADORA3 (0.47) | BRD4ATMMEN1KMT2ATRPM5 | |
| SCHEMBL11501249 | 0.64 | HTT (0.43) | BRD4ATMKMT2ATRPM5ALOX12 | |
| SCHEMBL11439316 | 0.64 | OPRK1 (0.41) | BRD4ATMKMT2ATRPM5ALOX12 | |
| SCHEMBL11441417 | 0.64 | SMARCA2 (0.44) | TRPM5ALOX12TRPM4PDE4DKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4157331-A | SEDATIVES, TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4153799-A | ANXIOLYTICS, SEDATIVES, ANTICONVULSANTS, MUSCLE RELAXANTS, PYRAZOLE INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4130716-A | ANXIOLYTICS, SEDATIVE, MUSCLE RELAXANT, ANTICONVULSANT | HOFFMANN-LA ROCHE INC. (US) | 1978-12-19 | — | — | US | disclosed |