Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11525453 | 0.84 | KMT2A (0.42) | GAAALDH1A1CYP2D6LMNATSHR | |
| SCHEMBL11467386 | 0.76 | TSHR (0.35) | CYP2D6LMNATSHRKMT2A | |
| SCHEMBL11526006 | 0.75 | EZH2 (0.34) | CYP2D6LMNATSHRKMT2A | |
| SCHEMBL11527304 | 0.73 | KMT2A (0.42) | GAAALDH1A1CYP2D6LMNATSHR | |
| SCHEMBL11526004 | 0.73 | CYP2D6 (0.36) | CYP2D6LMNATSHRKMT2A | |
| SCHEMBL11526398 | 0.73 | KMT2A (0.42) | GAAALDH1A1CYP2D6LMNATSHR | |
| SCHEMBL11523500 | 0.68 | GAA (0.50) | MAPTGAAALDH1A1ALOX12LMNA | |
| SCHEMBL20641830 | 0.68 | ALDH1A1 (0.36) | ALDH1A1CYP2D6TP53LMNATSHR | |
| SCHEMBL10991831 | 0.68 | GAA (0.39) | GAAALDH1A1CYP2D6LMNATSHR | |
| SCHEMBL20052742 | 0.68 | HTR2C (0.53) | GAAALDH1A1LMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177186-A | 4-SILOXY-DERIVATIVES OF STERICALLY HINDERED PIPERIDINES | CIBA-GEIGY CORPORATION (US) | 1979-12-04 | — | — | US | disclosed |