Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11527978 | 0.84 | OPRM1 (0.44) | KMT2ANPC1RAB9AALDH1A1ALOX5 | |
| SCHEMBL3842681 | 0.74 | TAAR1 (0.48) | KMT2ANPC1RAB9AALDH1A1ALOX5 | |
| SCHEMBL29636497 | 0.72 | TAAR1 (0.54) | ALDH1A1TAAR1ATM | |
| SCHEMBL968919 | 0.72 | NPC1 (0.67) | KMT2ANPC1RAB9A | |
| SCHEMBL11528680 | 0.72 | LMNA (0.42) | KMT2ANPC1RAB9AALDH1A1OPRM1 | |
| SCHEMBL19027679 | 0.69 | ALDH1A1 (0.65) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL27669824 | 0.69 | TDP1 (0.50) | KMT2ANPC1RAB9AALDH1A1ALOX5 | |
| SCHEMBL353132 | 0.67 | HDAC2 (0.68) | KMT2ANPC1RAB9AALDH1A1KEAP1 | |
| SCHEMBL11568815 | 0.67 | NPC1 (0.50) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6036284 | 0.67 | NPC1 (0.50) | KMT2ANPC1RAB9AALDH1A1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156735-A | SALIDIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| US-4118501-A | SALIDIURETIC ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |