Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 9/20 | 0.40 |
| ▸ | CA2 | P00918 | 9/20 | 0.40 |
| ▸ | CA9 | Q16790 | 9/20 | 0.40 |
| ▸ | CA12 | O43570 | 8/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064455 | 0.87 | LMNA (0.55) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL7105307 | 0.87 | LMNA (0.55) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13064456 | 0.80 | PRKAB2 (0.49) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13064460 | 0.80 | ADK (0.54) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL24371902 | 0.79 | LMNA (1.00) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL19370230 | 0.79 | ALDH1A1 (0.69) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL21798516 | 0.79 | LMNA (1.00) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL22826797 | 0.79 | LMNA (1.00) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL5983791 | 0.79 | LMNA (1.00) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13062149 | 0.79 | LMNA (1.00) | LMNAALDH1A1TP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140851-A | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1979-02-20 | — | — | US | claimed |
| US-4140851-A | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1979-02-20 | — | — | US | disclosed |