Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20203666 | 0.76 | ALDH1A1 (0.57) | GAAKMT2AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL24151176 | 0.76 | HPGD (0.44) | HTTGAANPC1RAB9ANPSR1 | |
| SCHEMBL7107767 | 0.76 | ALDH1A1 (0.57) | GAAKMT2AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6811055 | 0.75 | HPGD (0.47) | HTTGAANPC1RAB9ANPSR1 | |
| SCHEMBL18476884 | 0.74 | KMT2A (0.43) | HTTKMT2ALMNAPOLBMEN1 | |
| SCHEMBL11524848 | 0.72 | MGLL (0.54) | HTTL3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL4028484 | 0.70 | HPGD (0.60) | GAAKMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL7478058 | 0.69 | ALDH1A1 (0.50) | GAAMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL24069592 | 0.69 | HPGD (0.38) | HTTGAANPC1RAB9ANPSR1 | |
| SCHEMBL14930583 | 0.69 | ALDH1A1 (0.50) | GAAMAPTHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156735-A | SALIDIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| US-4118501-A | SALIDIURETIC ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |