Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11535390 | 0.80 | DAO (0.41) | PIM1DAOGPR35USP2POLB | |
| SCHEMBL11536698 | 0.78 | ALDH1A1 (0.46) | PIM1USP2POLBMAPTKDM4E | |
| SCHEMBL11532265 | 0.78 | RAB9A (0.50) | PIM1GPR35POLBHPGDMAPT | |
| SCHEMBL11537169 | 0.75 | PIM1 (0.40) | PIM1DAOGPR35POLBHPGD | |
| SCHEMBL11532310 | 0.74 | MAPT (0.48) | DAOGPR35USP2POLBHPGD | |
| SCHEMBL11532255 | 0.73 | ALDH1A1 (0.48) | PIM1DAOGPR35USP2POLB | |
| SCHEMBL11166639 | 0.69 | PIM1 (0.32) | PIM1DAOGPR35USP2POLB | |
| SCHEMBL10852840 | 0.68 | PIM1 (0.37) | PIM1DAOGPR35USP2POLB | |
| SCHEMBL10862875 | 0.68 | PIM1 (0.40) | PIM1DAOGPR35USP2POLB | |
| SCHEMBL10658912 | 0.67 | MAPK1 (0.42) | HPGDHSD17B10KCNK3KCNK9ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154742-A | DIURETICS | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4085117-A | DIURETIC-SALURETIC, URICOSURIC, HYPOTENSIVE, ANTIKALURETIC AGENTS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |