Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT known ✓ | P43490 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9886621 | 0.97 | KDM4E (0.51) | MAPTKDM4EALDH1A1LMNARAB9A | |
| Hydrochloric Acid SCHEMBL11530947 | 0.95 | KDM4E (0.50) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL13677547 | 0.83 | LMNA (0.51) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL11535686 | 0.79 | SMN1; SMN2 (0.46) | KDM4EALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL12269122 | 0.79 | HDAC6 (0.43) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL23479165 | 0.78 | NPC1 (0.46) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL14288354 | 0.78 | HDAC6 (0.45) | MAPTKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL11527429 | 0.76 | KMT2A (0.48) | MAPTKDM4ELMNASMN1; SMN2KMT2A | |
| SCHEMBL11534871 | 0.75 | KDM4E (0.60) | MAPTKDM4ELMNARAB9ANPC1 | |
| SCHEMBL18405588 | 0.75 | ACSS2 (0.40) | MAPTKDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4142886-A | Substituted benzimidazole compounds and use as herbicides | UNITED STATES BORAX & CHEMICAL CORPORATION (US) | 1979-03-06 | — | — | US | disclosed |