Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534725 | 0.79 | CHEK1 (0.51) | CHEK1PDGFRACDK5DYRK1ALRRK2 | |
| SCHEMBL11746654 | 0.78 | CHEK1 (0.53) | CHEK1PDGFRACDK5DYRK1ALRRK2 | |
| SCHEMBL11537172 | 0.76 | DCTPP1 (0.34) | DCTPP1CHEK1PDGFRACDK5DYRK1A | |
| SCHEMBL11750120 | 0.74 | BRPF1 (0.42) | CHEK1PDGFRACDK5DYRK1ALRRK2 | |
| SCHEMBL27940630 | 0.65 | SMN1; SMN2 (0.47) | KCNH2KDM4EALDH1A1TSHRMAPT | |
| SCHEMBL23789712 | 0.63 | MEN1 (0.51) | KCNH2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL11861701 | 0.62 | MEN1 (0.40) | KCNH2ALDH1A1MAPTSMN1; SMN2CYP19A1 | |
| SCHEMBL21312981 | 0.61 | MEN1 (0.49) | KCNH2KDM4ETDP1PLK1SMN1; SMN2 | |
| SCHEMBL11745480 | 0.61 | CHEK1 (0.60) | CHEK1PDGFRACDK5DYRK1ALRRK2 | |
| SCHEMBL4286994 | 0.59 | LIPG (0.50) | KCNH2TSHRTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134914-A | 1-Acyl-4-substituted phenyl thiosemicarbazides | ELI LILLY AND COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4082762-A | 4-(2-HALOPHENYL)-1,2,4-TRIAZOLE-3-THIOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-3937713-A | Process for the preparation of s-triazolo[3,4-b]benzothiazoles | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | disclosed |