Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Picotrin SCHEMBL2109455 | 0.84 | P4HTM (0.50) | P4HTMKDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL11534846 | 0.83 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNAMAPTMRGPRX4 | |
| SCHEMBL11536087 | 0.82 | KMT2A (0.50) | P4HTMKDM4EL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL11536461 | 0.81 | KDM4E (0.49) | P4HTMKDM4EL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL11535031 | 0.81 | KCNN4 (0.46) | P4HTMKDM4EALDH1A1MAPK1P4HA1 | |
| SCHEMBL11540602 | 0.80 | P4HTM (0.51) | P4HTMKDM4EL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL11535667 | 0.80 | KIF11 (0.40) | MEN1KMT2AKIF11SMN1; SMN2 | |
| SCHEMBL11538682 | 0.79 | P4HTM (0.45) | P4HTMKDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL11534919 | 0.78 | KMO (0.47) | P4HTMKDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL11533308 | 0.78 | KMO (0.53) | KDM4EMEN1ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139625-A | 5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |
| US-4133887-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127662-A | ANTIACNE | SCHERING CORPORATION (US) | 1978-11-28 | — | — | US | disclosed |
| US-4123433-A | ANTIACNE AGENTS | SCHERING CORPORATION (US) | 1978-10-31 | — | — | US | disclosed |
| US-4044140-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |