Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.46 |
| ▸ | FPR2 | P25090 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544485 | 0.88 | SCN9A (0.46) | SCN9AFPR2LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL11545575 | 0.88 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2PTGER4PTGER2MEN1 | |
| SCHEMBL11545135 | 0.88 | TTR (0.49) | NPSR1 | |
| SCHEMBL11545459 | 0.87 | F2 (0.43) | SCN9AFPR2LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL756150 | 0.82 | MAPT (0.53) | SCN9AFPR2LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL11540799 | 0.79 | SCN9A (0.45) | SCN9AFPR2SMN1; SMN2PTGER4IGFBP3 | |
| SCHEMBL10277127 | 0.78 | PTGS1 (0.46) | LMNAL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10277124 | 0.78 | PTGS1 (0.46) | LMNAL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10277125 | 0.78 | PTGS1 (0.46) | LMNAL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11540801 | 0.76 | MAOB (0.48) | SCN9ALMNASCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151302-A | Araliphatic dihalogen compounds composition and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-04-24 | — | — | US | disclosed |
| US-4057647-A | Araliphatic dihalogen compounds and process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-11-08 | — | — | US | disclosed |