Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | CPS1 | P31327 | 1/20 | 0.38 |
| ▸ | PNLIP | P16233 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544488 | 0.86 | MAOB (0.50) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL11545463 | 0.86 | MAOB (0.48) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL17996051 | 0.82 | P2RX3 (0.55) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL22407068 | 0.82 | MAOB (0.68) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL22406928 | 0.80 | CYP11B1 (0.48) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL11540804 | 0.78 | MAOB (0.47) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL22406882 | 0.77 | MAOB (0.46) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL11540797 | 0.76 | SCN9A (0.46) | LMNASCN9ASCN8ASCN10A | |
| SCHEMBL5255602 | 0.75 | MAOB (0.52) | MAOBMAOACYP11B1CYP11B2P2RX3 | |
| SCHEMBL5260362 | 0.75 | MAOB (0.49) | MAOBMAOACYP11B1CYP11B2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151302-A | Araliphatic dihalogen compounds composition and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-04-24 | — | — | US | disclosed |
| US-4057647-A | Araliphatic dihalogen compounds and process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-11-08 | — | — | US | disclosed |