Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 5/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622117 | 0.83 | LOXL2 (0.47) | LOXL2LOXGRIN1GRIN2BRXRA | |
| SCHEMBL3404211 | 0.82 | L3MBTL1 (0.38) | LOXL2LOXPDPK1FFAR1RAB9A | |
| SCHEMBL18200291 | 0.82 | NOS3 (0.38) | LOXL2LOXNOS3NOS1NOS2 | |
| SCHEMBL19932063 | 0.80 | NOS3 (0.37) | LOXL2LOXNOS3NOS1NOS2 | |
| SCHEMBL20893799 | 0.80 | GRIN1 (0.38) | NOS3NOS1NOS2PDPK1CCR1 | |
| SCHEMBL16815694 | 0.80 | CCR1 (0.39) | NOS3NOS1NOS2PDPK1CCR1 | |
| SCHEMBL29763523 | 0.80 | GRIN1 (0.38) | LOXL2LOXNOS3NOS1NOS2 | |
| SCHEMBL22905296 | 0.77 | FFAR1 (0.36) | LOXL2LOXNOS3NOS1NOS2 | |
| SCHEMBL21567109 | 0.77 | GRIN1 (0.36) | NOS3NOS1NOS2PDPK1CCR1 | |
| SCHEMBL25202584 | 0.76 | GRIN1 (0.38) | LOXL2GRIN1GRIN2BRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007115-A | Pyrimidylmethyl sulfonamide compounds | BASF SE | 2011-04-06 | — | — | CN | disclosed |
| US-20110077153-A1 | Substituted Heteroarylmethyl Sulfonamides | BASF SE (DE) | 2011-03-31 | — | — | US | disclosed |
| US-20110039693-A1 | Pyrimidylmethyl Sulfonamide Compounds | BASF SE (DE) | 2011-02-17 | — | — | US | disclosed |
| EP-2252606-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009141291-A1 | SUBSTITUTED HETEROARYLMETHYL SULFONAMIDES | BASF SE (DE) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009101078-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009101079-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039693-A1 | Pyrimidylmethyl Sulfonamide Compounds | TPMT, NQO2, TST | LOXL2 2635/4885LOX 1117/4885NOS3 167/4885 |
| US-20110077153-A1 | Substituted Heteroarylmethyl Sulfonamides | ARSA, STS, CCNY | LOXL2 3143/4885LOX 2311/4885NOS3 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.