Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11552670 | 0.92 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11546637 | 0.90 | MAPT (0.62) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11545316 | 0.90 | DRD2 (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11547592 | 0.88 | MAPT (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11474850 | 0.88 | ADRA2A (0.74) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11545710 | 0.85 | ADRA2A (0.83) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11544404 | 0.85 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11545766 | 0.84 | PKM (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL708228 | 0.83 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Indoramin SCHEMBL29370437 | 0.81 | ADRA1D (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177279-A | 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions | JOHN WYETH & BROTHER LTD. (GB) | 1979-12-04 | — | — | US | claimed |
| US-4177279-A | 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions | JOHN WYETH & BROTHER LTD. (GB) | 1979-12-04 | — | — | US | disclosed |