Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 1/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 9/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29503863 | 0.90 | ELANE (0.38) | SLC6A1SLC6A11ELANECYP2D6CYP1A2 | |
| SCHEMBL7379917 | 0.80 | KMT2A (0.42) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL7373953 | 0.80 | KMT2A (0.42) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL11547645 | 0.80 | HTR2C (0.42) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL11546734 | 0.79 | KIF11 (0.40) | ELANECYP2D6CYP1A2CYP2C19KIF11 | |
| SCHEMBL11544261 | 0.78 | ELANE (0.38) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL7582887 | 0.78 | TDP1 (0.46) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL11546196 | 0.77 | ALDH1A1 (0.42) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL11545881 | 0.77 | IDO1 (0.43) | ELANECYP2D6CYP1A2CYP2C19HTR2C | |
| SCHEMBL11153901 | 0.77 | KMT2A (0.47) | ELANECYP2D6CYP1A2CYP2C19HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |