Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.45 |
| ▸ | TUBB | P07437 | 3/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544032 | 0.87 | TUBB4A (0.45) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11547198 | 0.80 | TUBB4A (0.49) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3309109 | 0.76 | TUBB4A (0.60) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11548967 | 0.73 | ALDH1A1 (0.47) | KMT2AL3MBTL1ALDH1A1TDP1KDM4E | |
| SCHEMBL1340341 | 0.73 | L3MBTL1 (0.58) | KMT2AL3MBTL1MEN1ALDH1A1TDP1 | |
| SCHEMBL8076951 | 0.72 | L3MBTL1 (0.62) | KMT2AL3MBTL1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL11186265 | 0.72 | KMT2A (0.55) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11545105 | 0.72 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1TDP1GAAMAPT | |
| SCHEMBL8653049 | 0.72 | HRH4 (0.59) | KMT2AALDH1A1TDP1NR4A2KDM4E | |
| SCHEMBL27706779 | 0.71 | NR4A2 (0.54) | KMT2ATUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |