Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545098 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EL3MBTL1MAPT | |
| SCHEMBL11546010 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDPABPC1EIF4HKDM4E | |
| SCHEMBL11545885 | 0.76 | MAPT (0.47) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL11544030 | 0.76 | LMNA (0.45) | ALDH1A1HPGDKDM4EMAPTNPSR1 | |
| SCHEMBL11545103 | 0.73 | KMT2A (0.49) | ALDH1A1KDM4EHSD17B10L3MBTL1MAPT | |
| SCHEMBL11548970 | 0.73 | L3MBTL1 (0.44) | ALDH1A1HPGDKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL11548971 | 0.73 | L3MBTL1 (0.44) | ALDH1A1HPGDKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL11544475 | 0.73 | FAAH (0.45) | ALDH1A1HPGDMAPTTDP1SMN1; SMN2 | |
| SCHEMBL1340341 | 0.72 | L3MBTL1 (0.58) | ALDH1A1HPGDL3MBTL1MAPTTDP1 | |
| SCHEMBL8076951 | 0.72 | L3MBTL1 (0.62) | ALDH1A1HPGDL3MBTL1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |