SCHEMBL11545567

SCHEMBL11545567

CN(C)c1ccc2sc(=O)[nH]c(=O)c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.50
PDE3B Q13370 2/20 0.45
PDE3A Q14432 2/20 0.45
IP6K1 Q92551 1/20 0.43
PIM1 P11309 3/20 0.41
PIM2 Q9P1W9 3/20 0.41
AR P10275 2/20 0.40
ALDH1A1 P00352 4/20 0.38
CMA1 P23946 1/20 0.38
MAPT P10636 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
GUSB P08236 1/20 0.36
HSD17B10 Q99714 3/20 0.36
HPGD P15428 2/20 0.36
THRB P10828 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 2/20 0.34
GLA P06280 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11546532 0.80 APAF1 (0.37) KDM4EPDE3BPDE3APIM1PIM2
SCHEMBL11341012 0.77 PDE3B (0.54) KDM4EPDE3BPDE3AARALDH1A1
SCHEMBL11542785 0.77 PIM1 (0.45) KDM4EPDE3BPDE3APIM1PIM2
SCHEMBL2080433 0.77 KDM4E (0.48) KDM4EPDE3BPDE3AIP6K1PIM1
SCHEMBL11543811 0.74 PARP1 (0.50) PDE3BPDE3APIM1PIM2AR
SCHEMBL11540248 0.74 POLB (0.44) KDM4EALDH1A1CMA1MAPTGAA
SCHEMBL11538149 0.74 CMA1 (0.41) PDE3BPDE3APIM1PIM2CMA1
SCHEMBL6238353 0.74 PIM1 (0.44) PIM1PIM2CMA1MAPTHPGD
SCHEMBL11540933 0.73 CMA1 (0.38) PDE3BPDE3APIM1PIM2AR
SCHEMBL11538159 0.73 KIF11 (0.44) PDE3BPDE3APIM1PIM2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140532-A ORGANIC SILVER SALT, CATALYST, REDUCING AGENT, 2H-1,3-BENZOTHIAZIN-2,4(3H-)DIONE FUJI PHOTO FILM CO., LTD. (JP) 1979-02-20 US disclosed