Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546010 | 0.87 | ALDH1A1 (0.54) | KMT2APKMEGFRALDH1A1L3MBTL1 | |
| SCHEMBL11547919 | 0.85 | CYP1A2 (0.47) | KMT2APKMMCL1EGFRALDH1A1 | |
| SCHEMBL11546013 | 0.82 | MCL1 (0.40) | KMT2APKMMCL1EGFRALDH1A1 | |
| SCHEMBL11545098 | 0.80 | ALDH1A1 (0.47) | KMT2APKMMCL1ALDH1A1L3MBTL1 | |
| SCHEMBL10412134 | 0.78 | KMT2A (0.55) | KMT2APKMMCL1EGFRALDH1A1 | |
| SCHEMBL2662567 | 0.75 | EGFR (0.54) | KMT2APKMMCL1EGFRALDH1A1 | |
| SCHEMBL11544030 | 0.72 | LMNA (0.45) | KMT2APKMMCL1ALDH1A1NPSR1 | |
| SCHEMBL752325 | 0.71 | KDM1A (0.51) | KMT2APKMEGFRALDH1A1L3MBTL1 | |
| SCHEMBL11544861 | 0.71 | MAPT (0.47) | KMT2APKMALDH1A1L3MBTL1GAA | |
| SCHEMBL30639179 | 0.70 | KDM4E (0.67) | KMT2APKMMCL1EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |