Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635674 | 0.84 | ALDH1A1 (0.55) | MAPTRAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL1749364 | 0.83 | MAPK14 (0.54) | MAPTRAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL314260 | 0.83 | KMT2A (0.54) | MAPTRAB9ANPC1MEN1ALDH1A1 | |
| Propane SCHEMBL27304878 | 0.81 | KMT2A (0.53) | MAPTRAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL11545584 | 0.79 | ALDH1A1 (0.49) | RAB9ANPC1PTGS2MEN1ALDH1A1 | |
| SCHEMBL2080446 | 0.77 | CES2 (0.49) | MAPTRAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL11541038 | 0.77 | PTGS2 (0.42) | MAPTRAB9ANPC1PTGS2MEN1 | |
| SCHEMBL11541042 | 0.77 | PTGS2 (0.42) | MAPTRAB9ANPC1PTGS2MEN1 | |
| SCHEMBL11540691 | 0.77 | CYP2C19 (0.46) | MAPTRAB9ANPC1PTGS2MEN1 | |
| SCHEMBL28260150 | 0.76 | ALDH1A1 (0.47) | MAPTMEN1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151302-A | Araliphatic dihalogen compounds composition and method of use | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-04-24 | — | — | US | disclosed |
| US-4057647-A | Araliphatic dihalogen compounds and process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-11-08 | — | — | US | disclosed |