Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556805 | 0.89 | STAT3 (0.45) | ALDH1A1KDM4ECYP2C19SLC22A12LMNA | |
| SCHEMBL11554551 | 0.82 | CYP2C19 (0.57) | CYP2C9CYP3A4ALDH1A1TSHRCYP2C19 | |
| SCHEMBL1287495 | 0.76 | CYP2C9 (0.60) | CYP2C9ALDH1A1SMN1; SMN2CYP2C19SLC22A12 | |
| SCHEMBL11561612 | 0.71 | RAB9A (0.59) | ALDH1A1SMN1; SMN2KDM4EACLYKMT2A | |
| SCHEMBL11553624 | 0.70 | CYP2C19 (0.53) | CYP2C9CYP2C19LMNAMAPTHTT | |
| SCHEMBL11560887 | 0.70 | CNR2 (0.53) | SMN1; SMN2TSHRACLYCYP2C19KMT2A | |
| SCHEMBL11556111 | 0.70 | CYP2C19 (0.60) | CYP2C9CYP3A4ALDH1A1TSHRCYP2C19 | |
| SCHEMBL1288046 | 0.69 | CYP2C19 (0.63) | CYP2C9CYP3A4ALDH1A1TSHRCYP2C19 | |
| SCHEMBL11550671 | 0.68 | SLC22A12 (0.64) | CYP2C9ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL11550650 | 0.68 | SLC22A12 (0.64) | CYP2C9CYP3A4ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |