Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 6/20 | 0.57 |
| ▸ | EYA3 | Q99504 | 5/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556111 | 0.87 | CYP2C19 (0.60) | CYP2C19EYA3SLC22A12CYP2C9MEN1 | |
| SCHEMBL11553624 | 0.86 | CYP2C19 (0.53) | CYP2C19EYA3CYP2C9LMNAPOLB | |
| SCHEMBL11557937 | 0.82 | CYP2C9 (0.41) | CYP2C19SLC22A12CYP2C9MEN1LMNA | |
| SCHEMBL11552492 | 0.79 | EYA3 (0.52) | CYP2C19EYA3SLC22A12CYP2C9MEN1 | |
| SCHEMBL1287955 | 0.78 | EYA3 (0.68) | CYP2C19EYA3SLC22A12CYP2C9MEN1 | |
| SCHEMBL11557882 | 0.78 | RAB9A (0.43) | LMNAKMT2APOLBMAPTHSD17B10 | |
| SCHEMBL11556834 | 0.77 | EYA3 (0.61) | EYA3TTRNR1H4PTPN1THRB | |
| SCHEMBL11558937 | 0.77 | CYP2C19 (0.53) | CYP2C19EYA3CYP2C9LMNAPOLB | |
| SCHEMBL11559523 | 0.77 | CYP2C19 (0.64) | CYP2C19EYA3SLC22A12CYP2C9MEN1 | |
| SCHEMBL11560887 | 0.77 | CNR2 (0.53) | CYP2C19MEN1LMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |