Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2737208 | 0.78 | LMNA (0.92) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL19468767 | 0.78 | F2 (0.67) | LMNAALDH1A1KDM4EF2PRSS1 | |
| Hydrochloric Acid SCHEMBL5155050 | 0.77 | LMNA (0.65) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL31272185 | 0.77 | LMNA (0.65) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3196752 | 0.77 | LMNA (0.65) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL636283 | 0.77 | LMNA (0.63) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL24511136 | 0.75 | F2 (0.69) | LMNAALDH1A1KDM4EF2PRSS1 | |
| Hydrochloric Acid SCHEMBL11598831 | 0.74 | LMNA (0.61) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL5293777 | 0.74 | LMNA (0.61) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 | |
| SCHEMBL8085263 | 0.74 | LMNA (0.61) | LMNAALDH1A1KDM4ENPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177131-A | 1-BENXYL PYRIDINIUM-3-CARBOXAMIDE | THE METALUX CORPORATION (US) | 1979-12-04 | — | — | US | disclosed |