Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5286396 | 0.98 | LMNA (0.61) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| SCHEMBL30192808 | 0.98 | LMNA (0.61) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| Bromide SCHEMBL17105097 | 0.96 | LMNA (0.62) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| SCHEMBL5074160 | 0.88 | LMNA (0.55) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| SCHEMBL4404405 | 0.85 | LMNA (0.62) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| Trifluoromethanesulfonic Acid SCHEMBL5674252 | 0.83 | LMNA (0.53) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL1250826 | 0.80 | ALDH1A1 (0.55) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| SCHEMBL5293777 | 0.78 | LMNA (0.61) | LMNAL3MBTL1RAB9AALDH1A1KDM4E | |
| Bromide SCHEMBL11580547 | 0.78 | PABPC1 (0.51) | LMNAL3MBTL1ALDH1A1KDM4EPABPC1 | |
| Hydrochloric Acid SCHEMBL3278043 | 0.78 | ALDH1A1 (0.79) | LMNARAB9AALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740572-A1 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103031-A1 | NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-03 | — | — | WO | disclosed |
| US-20050239826-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-27 | — | — | US | disclosed |
| US-5368774-A | Water soluble corrosion inhibitor effective against corrosion by carbon dioxide | BAKER HUGHES INCORPORATED (US) | 1994-11-29 | — | — | US | disclosed |
| EP-0339535-B1 | PLATING BATH FOR ELECTRODEPOSITION OF ALUMINUM AND PLATING PROCESS MAKING USE OF THE BATH | NISSHIN STEEL CO., LTD. (JP) | 1993-09-08 | — | — | EP | disclosed |
| US-4906342-A | Plating bath for electrodeposition of aluminum and plating process making use of the bath | NISSHIN STEEL CO., LTD. (JP) | 1990-03-06 | — | — | US | disclosed |
| EP-0339535-A1 | Plating bath for electrodeposition of aluminum and plating process making use of the bath | NISSHIN STEEL CO., LTD. (JP) | 1989-11-02 | — | — | EP | disclosed |
| US-4032596-A | QUATERNARY AMMONIUM SALTS, FREE RADICAL CATALYSTS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239826-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MCHR2, GPR119 | LMNA 2571/4885L3MBTL1 1329/4885RAB9A 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.