Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11563849 | 0.99 | OPRM1 (0.56) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL2985764 | 0.94 | CYP2D6 (0.60) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11455428 | 0.93 | CYP2D6 (0.58) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL11563209 | 0.91 | OPRM1 (0.55) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11566542 | 0.90 | OPRM1 (0.54) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL11565716 | 0.89 | KCNA3 (0.54) | OPRM1OPRD1KMT2AMEN1LMNA | |
| SCHEMBL7831915 | 0.88 | ALDH1A1 (0.54) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11564720 | 0.88 | KCNA3 (0.53) | OPRM1OPRD1KMT2AMEN1LMNA | |
| SCHEMBL11567112 | 0.87 | FAAH (0.55) | OPRM1OPRD1CYP2D6KMT2ALMNA | |
| SCHEMBL11561939 | 0.85 | NPFFR1 (0.53) | OPRM1OPRD1CYP2D6CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |