Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586504 | 0.75 | CTSC (0.32) | BACE1 | |
| SCHEMBL11568410 | 0.75 | MME (0.46) | BACE1 | |
| SCHEMBL11570840 | 0.73 | CTSS (0.36) | BACE1PSENENREN | |
| SCHEMBL5328622 | 0.72 | SLC1A3 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27766846 | 0.72 | AAK1 (0.34) | AAK1 | |
| SCHEMBL7269530 | 0.72 | SLC7A5 (0.45) | AAK1REN | |
| SCHEMBL11567951 | 0.71 | MMP1 (0.38) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29706226 | 0.70 | ERAP2 (0.36) | BACE1AAK1 | |
| SCHEMBL10481476 | 0.69 | CTSS (0.35) | — | |
| SCHEMBL3489862 | 0.68 | ANPEP (0.47) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4146614-A | TREATMENT OF SCHIZOPHRENIA | STATE OF MICHIGAN (US) | 1979-03-27 | — | — | US | disclosed |