Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9801787 | 0.77 | HSD11B1 (0.43) | SMN1; SMN2ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL28974082 | 0.75 | HTR6 (0.46) | AKR1B1HTR6FEN1TSHRSMN1; SMN2 | |
| SCHEMBL28912917 | 0.74 | MET (0.36) | AKR1B1HTR6FEN1TSHRSMN1; SMN2 | |
| SCHEMBL4243696 | 0.70 | MAP2K3 (0.47) | ALDH1A1KDM4EPARP1 | |
| (Phenylsulfonyl)Benzene SCHEMBL28297601 | 0.69 | HTR6 (0.74) | ABCB1ABCC1HTR6TSHRSMN1; SMN2 | |
| (Phenylsulfonyl)Benzene SCHEMBL8958296 | 0.69 | HTR6 (0.74) | ABCB1ABCC1HTR6TSHRSMN1; SMN2 | |
| (Phenylsulfonyl)Benzene SCHEMBL1736247 | 0.66 | MAPT (0.62) | ABCB1ABCC1HTR6TSHRSMN1; SMN2 | |
| SCHEMBL14564382 | 0.66 | DHODH (0.50) | PARP1 | |
| SCHEMBL3821371 | 0.66 | LMNA (0.41) | TSHRALDH1A1LMNA | |
| SCHEMBL16369913 | 0.66 | HTR6 (0.59) | AKR1B1HTR6FEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4132795-A | Benzenesulfonyl ureas and their use for the treatment of diabetes mellitus | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-02 | — | — | US | disclosed |
| US-4025519-A | HYPOGLYCEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-05-24 | — | — | US | disclosed |
| US-3962244-A | LOWERING OF BLOOD-SUGAR LEVELS | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |
| US-3939269-A | Benzenesulfon YL-semicarbazides for lowering blood sugar levels | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |