SCHEMBL11575971

SCHEMBL11575971

CN1CCC(=C2c3ccccc3Sc3ccc(F)cc32)CC1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SETD7 Q8WTS6 5/20 0.76
CHRM2 P08172 5/20 0.76
CHRM1 P11229 5/20 0.76
ADRA1A P35348 5/20 0.76
KCNH2 Q12809 5/20 0.76
ADRA2A P08913 4/20 0.76
DRD1 P21728 4/20 0.76
DRD3 P35462 4/20 0.76
HTR1A P08908 4/20 0.76
SLC6A2 P23975 3/20 0.76
SLC6A4 P31645 3/20 0.76
SLC6A3 Q01959 3/20 0.76
CYP2D6 P10635 3/20 0.76
CYP2C19 P33261 3/20 0.76
TBXA2R P21731 2/20 0.76
OPRM1 P35372 2/20 0.76
ADORA3 P0DMS8 1/20 0.76
HTT P42858 2/20 0.61
CYP3A4 P08684 2/20 0.61
DRD2 P14416 5/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11573964 0.92 KCNH2 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11575442 0.90 SETD7 (0.60) SETD7CHRM2CHRM1ADRA1AKCNH2
Pimethixene SCHEMBL301596 0.87 SETD7 (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
Pimethixene SCHEMBL29433731 0.87 SETD7 (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11574345 0.85 SETD7 (0.53) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11432245 0.84 HTR1A (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11574284 0.84 SETD7 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11424131 0.83 SETD7 (0.70) SETD7CHRM2CHRM1ADRA1AKCNH2
Fumaric Acid SCHEMBL11596650 0.82 HTT (0.80) SETD7CHRM2CHRM1ADRA1AKCNH2
Maleic Acid SCHEMBL11596646 0.82 HTT (0.80) SETD7CHRM2CHRM1ADRA1AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4086350-A FLUORO, CHLORO AND CYANO SUBSTITUTED 4-(9-XANTHENYLIDENE, 9-THIOXANTHENYLIDENE OR 11(6H)-DIBENZO(B,E)OXEPINYLIDENE)-1-METHYL-PIPERIDINES SMITHKLINE CORPORATION (US) 1978-04-25 US disclosed