Pimethixene

Pimethixene

SCHEMBL301596

CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SETD7 Q8WTS6 5/20 1.00
CHRM2 P08172 5/20 1.00
CHRM1 P11229 5/20 1.00
ADRA1A P35348 5/20 1.00
KCNH2 Q12809 5/20 1.00
ADRA2A P08913 4/20 1.00
DRD1 P21728 4/20 1.00
DRD3 P35462 4/20 1.00
HTR1A P08908 4/20 1.00
SLC6A2 P23975 3/20 1.00
SLC6A4 P31645 3/20 1.00
SLC6A3 Q01959 3/20 1.00
CYP2D6 P10635 3/20 1.00
CYP2C19 P33261 3/20 1.00
TBXA2R P21731 2/20 1.00
OPRM1 P35372 2/20 1.00
ADORA3 P0DMS8 1/20 1.00
HTT P42858 2/20 0.76
CYP3A4 P08684 2/20 0.76
HTR2A P28223 4/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pimethixene SCHEMBL29433731 1.00 SETD7 (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11432245 0.87 HTR1A (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
Pimethixene SCHEMBL301225 0.87 HTT (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11573964 0.87 KCNH2 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11574284 0.87 SETD7 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11573081 0.87 SETD7 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
Pimethixene SCHEMBL301226 0.87 HTT (1.00) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11575971 0.87 SETD7 (0.76) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11600806 0.85 DRD3 (0.73) SETD7CHRM2CHRM1ADRA1AKCNH2
SCHEMBL11431794 0.85 SETD7 (0.72) SETD7CHRM2CHRM1ADRA1AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 450 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
EP-4658278-A1 SELECTIVE FIASMA TREATMENT Valo Health, Inc. (US) 2025-12-10 EP claimed
WO-2024163699-A1 SELECTIVE FIASMA TREATMENT VALO HEALTH, INC. (US) 2024-08-08 WO claimed
US-20230321008-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) 2023-10-12 US claimed
EP-4171545-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) 2023-05-03 EP claimed
US-20220073444-A1 Compounds, Compositions, and Methods for use in Treating Autophagy-Associated Disorders BIOPHAGY INC (US) 2022-03-10 US claimed
WO-2021260152-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) 2021-12-30 WO claimed
US-11208371-B2 Compounds, compositions, and methods for use in treating autophagy-associated disorders BIOPHAGY INC (US) 2021-12-28 US claimed
US-20210235686-A1 RED BLOOD CELL STORAGE SOLUTIONS, SOLUTION ADDITIVES, AND METHODS FOR IMPROVING THE STORAGE OF RED BLOOD CELLS UNIVERSITY OF CINCINNATI 2021-08-05 US claimed
US-10736910-B2 Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits STC.UNM (US) 2020-08-11 US claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2007026151-A1 ANTIHISTAMINE- AND CORTICOSTEROID- CONTAINING LIPOSOME COMPOSITION AND ITS USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING RHINITIS AND RELATED DISORDERS BIOLIPOX AB (SE) 2007-03-08 WO claimed
WO-2006131737-A2 METHOD AND COMPOSITION FOR TREATING INFLAMMATORY DISORDERS BIOLIPOX AB (SE) 2006-12-14 WO claimed
EP-1641446-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF Pediamed Pharmaceuticals, Inc. (US) 2006-04-05 EP claimed
EP-1151295-A4 METHODS OF IDENTIFYING THERAPEUTICALLY EFFECTIVE ANTINEOPLASTIC AGENTS WITH CULTURED CELLS HAVING INTACT CELL MEMBRANES AND CORRESPONDING PRODUCTS CYTOVIA INC (US) 2005-03-30 EP claimed
US-20050059656-A1 Compositions and methods for protecting against mitochondria component-mediated pathology CORNELL RESEARCH FOUNDATION, INC. 2005-03-17 US claimed
WO-2004112771-A1 PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF PEDIAMED PHARMACEUTICALS, INC. (US) 2004-12-29 WO claimed
US-20040259809-A1 Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof PEDIAMED PHARMACEUTICALS, INC. 2004-12-23 US claimed
EP-1151295-A1 METHODS OF IDENTIFYING THERAPEUTICALLY EFFECTIVE ANTINEOPLASTIC AGENTS WITH CULTURED CELLS HAVING INTACT CELL MEMBRANES AND CORRESPONDING PRODUCTS Cytovia, Inc. (US) 2001-11-07 EP claimed
WO-2000045165-A1 METHODS OF IDENTIFYING THERAPEUTICALLY EFFECTIVE ANTINEOPLASTIC AGENTS WITH CULTURED CELLS HAVING INTACT CELL MEMBRANES AND CORRESPONDING PRODUCTS CYTOVIA, INC. (US) 2000-08-03 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells SMPD3, SMPD4, CMA1 SETD7 1789/4885CHRM2 100/4885CHRM1 246/4885
US-20230321008-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE SMPD2, SMPD1, SMPD3 SETD7 2912/4885CHRM2 1663/4885CHRM1 1851/4885
US-11208371-B2 Compounds, compositions, and methods for use in treating autophagy-associated disorders BECN1, ATG7, SQSTM1 SETD7 4670/4885CHRM2 3916/4885CHRM1 4294/4885
US-20220073444-A1 Compounds, Compositions, and Methods for use in Treating Autophagy-Associated Disorders BECN1, ATG7, SQSTM1 SETD7 4670/4885CHRM2 3916/4885CHRM1 4294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.