Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742887 | 0.87 | GPR84 (0.42) | LMNAHTTKDM4ERAB9AGPR84 | |
| SCHEMBL3380819 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1KMT2APOLBHTR2C | |
| SCHEMBL10512676 | 0.82 | ADRB1 (0.38) | LMNAHTTKDM4EMAPK1RAB9A | |
| SCHEMBL4797771 | 0.81 | GPR84 (0.39) | LMNAHTTKDM4ERAB9AGPR84 | |
| SCHEMBL11577773 | 0.81 | GPR84 (0.39) | LMNAHTTKDM4EMAPK1RAB9A | |
| SCHEMBL6985439 | 0.81 | MAPK1 (0.48) | LMNAHTTKDM4EMAPK1RAB9A | |
| SCHEMBL8149052 | 0.79 | CCNT1 (0.44) | GPR84KMT2AHTR2A | |
| SCHEMBL9456621 | 0.78 | GPR84 (0.54) | LMNAHTTKDM4EMAPK1RAB9A | |
| SCHEMBL5261760 | 0.75 | GPR84 (0.46) | LMNAHTTKDM4EMAPK1RAB9A | |
| SCHEMBL5260086 | 0.74 | GPR84 (0.47) | LMNAHTTKDM4EMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177279-A | 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions | JOHN WYETH & BROTHER LTD. (GB) | 1979-12-04 | — | — | US | disclosed |