Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7186269 | 0.83 | KDM4E (0.45) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL11577771 | 0.82 | LMNA (0.44) | KDM4EALDH1A1POLBHTR2CADRA1D | |
| SCHEMBL742887 | 0.81 | GPR84 (0.42) | KDM4EALDH1A1HTR2CADRB2KMT2A | |
| SCHEMBL25758177 | 0.78 | KDM4E (0.63) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL30415306 | 0.76 | KDM4E (0.83) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL3256692 | 0.76 | KDM4E (0.83) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL4797771 | 0.75 | GPR84 (0.39) | KDM4EATMALDH1A1POLBHTR2C | |
| Hydrochloric Acid SCHEMBL27732898 | 0.74 | KDM4E (0.81) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL30909145 | 0.73 | KDM4E (0.58) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL11039324 | 0.73 | KDM4E (0.58) | KDM4EATMBRD4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723105-B1 | BICYCLIC SUBSTITUTED INDOLE-DERIVATIVE STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | LILLY CO ELI (US) | 2013-05-15 | — | — | EP | disclosed |
| US-7728150-B2 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070185161-A1 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2007-08-09 | — | — | US | disclosed |
| EP-1723105-A1 | BICYCLIC SUBSTITUTED INDOLE-DERIVATIVE STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | ELI LILLY AND COMPANY (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2005092854-A1 | BICYCLIC SUBSTITUTED INDOLE-DERIVATIVE STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185161-A1 | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators | NR5A1, NR3C2, NR1H2 | KDM4E 3665/4885ATM 2228/4885BRD4 642/4885 |
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | NR3C2, NR5A1, MC2R | KDM4E 3154/4885ATM 3712/4885BRD4 744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.