Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577771 | 0.81 | LMNA (0.44) | GPR84FFAR1LMNAHTTKDM4E | |
| SCHEMBL742887 | 0.75 | GPR84 (0.42) | GPR84FFAR1LMNAHTTKDM4E | |
| SCHEMBL4797771 | 0.74 | GPR84 (0.39) | GPR84FFAR1LMNAHTTKDM4E | |
| SCHEMBL3380819 | 0.70 | KDM4E (0.54) | KDM4EKMT2AHTR2CALDH1A1POLB | |
| SCHEMBL6157434 | 0.69 | GPR84 (0.55) | GPR84FFAR1LMNAHTTMAPT | |
| SCHEMBL6985439 | 0.68 | MAPK1 (0.48) | GPR84FFAR1LMNAHTTKDM4E | |
| SCHEMBL1066163 | 0.68 | CYP17A1 (0.51) | GPR84FFAR1LMNAMAPK1MAPT | |
| SCHEMBL29611508 | 0.67 | GPR84 (0.51) | GPR84FFAR1LMNAHTTMAPT | |
| SCHEMBL9060404 | 0.67 | GPR84 (0.51) | GPR84FFAR1LMNAHTTMAPT | |
| SCHEMBL11374722 | 0.67 | GPR84 (0.51) | GPR84FFAR1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177279-A | 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions | JOHN WYETH & BROTHER LTD. (GB) | 1979-12-04 | — | — | US | disclosed |