Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9456621 | 0.81 | GPR84 (0.54) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL11577771 | 0.81 | LMNA (0.44) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL5261760 | 0.79 | GPR84 (0.46) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL5260086 | 0.77 | GPR84 (0.47) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL28293849 | 0.77 | LMNA (0.44) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL17232879 | 0.75 | GPR84 (0.62) | GPR84FFAR1ALDH1A1MAPTHTR2A | |
| SCHEMBL28093308 | 0.75 | P4HB (0.44) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL28295738 | 0.74 | OPRL1 (0.44) | MAPK1HTTLMNAKDM4EJAK2 | |
| SCHEMBL6888701 | 0.71 | GPR84 (0.56) | GPR84FFAR1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL5641546 | 0.71 | GPR84 (0.56) | GPR84FFAR1ALDH1A1MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |