Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578654 | 0.84 | RAB9A (0.40) | MAPTRAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL11580678 | 0.83 | RAB9A (0.39) | MAPTRAB9ATP53SMN1; SMN2NPSR1 | |
| SCHEMBL11581907 | 0.83 | RAB9A (0.58) | MAPTRAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL11579313 | 0.83 | MAPT (0.44) | MAPTRAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL11882975 | 0.82 | MAPT (0.47) | MAPTRAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL11578600 | 0.81 | MAP2K2 (0.44) | LMNAHPGDCYP1A2CYP2C19MEN1 | |
| SCHEMBL11579511 | 0.81 | MEN1 (0.56) | RAB9ATP53SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4094802 | 0.80 | KDM4E (0.52) | MAPTRAB9ASMN1; SMN2ALDH1A1ALOX12 | |
| SCHEMBL11580082 | 0.79 | ALDH1A1 (0.51) | MAPTTP53ALDH1A1LMNAMEN1 | |
| SCHEMBL11095111 | 0.79 | KIF11 (0.45) | MAPTRAB9AALDH1A1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |