Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 5/20 | 0.61 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11580335 | 1.00 | DRD4 (0.65) | DRD4CYP3A4HTR4DRD2DRD3 | |
| SCHEMBL11397386 | 0.94 | DRD4 (0.72) | DRD4HTR4 | |
| SCHEMBL10553783 | 0.88 | HTR4 (0.65) | DRD4HTR4DRD2DRD3 | |
| SCHEMBL11457053 | 0.84 | HTR4 (0.69) | DRD4CYP3A4HTR4DRD2DRD3 | |
| SCHEMBL9644656 | 0.84 | HTR4 (0.68) | HTR4DRD2 | |
| Fumaric Acid SCHEMBL11546983 | 0.83 | CYP3A4 (0.73) | CYP3A4HTR4 | |
| Fumaric Acid SCHEMBL11546990 | 0.83 | CYP3A4 (0.73) | CYP3A4HTR4 | |
| SCHEMBL9645517 | 0.82 | HTR4 (0.73) | HTR4DRD2 | |
| SCHEMBL11002126 | 0.81 | HTR4 (0.74) | HTR4DRD2 | |
| SCHEMBL11079701 | 0.80 | DRD4 (0.64) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4109005-A | METHOD OF INCREASING RATE OF GASTRIC EMPTYING WITH PYRROLIDINYLBENZAMIDES | A. H. ROBINS COMPANY, INC. (US) | 1978-08-22 | — | — | US | claimed |