SCHEMBL11589595

SCHEMBL11589595

CNc1ccc2c(C)cc(=O)n(C)c2n1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 7/20 0.44
KDM4E B2RXH2 3/20 0.44
CYP19A1 P11511 6/20 0.42
KAT2B Q92831 1/20 0.41
BRD9 Q9H8M2 3/20 0.39
BRD7 Q9NPI1 2/20 0.39
PARG Q86W56 1/20 0.36
PDE3B Q13370 1/20 0.34
PDE3A Q14432 1/20 0.34
ADORA1 P30542 1/20 0.34
HSD17B10 Q99714 1/20 0.33
NCF1 P14598 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11589892 0.80 ADORA1 (0.52) NQO2KDM4ECYP19A1BRD9BRD7
SCHEMBL11588815 0.75 NCF1 (0.34) KDM4EPDE3BPDE3AHSD17B10NCF1
SCHEMBL11591247 0.74 NQO2 (0.44) NQO2KDM4ECYP19A1KAT2BBRD9
SCHEMBL25703950 0.70 NQO2 (0.54) NQO2KDM4ECYP19A1HPGDHTT
SCHEMBL24072835 0.69 MAPT (0.38) NQO2KDM4ECYP19A1BRD9BRD7
SCHEMBL13064335 0.68 NCF1 (0.33) NCF1
SCHEMBL30979846 0.66 CDK4 (0.41) ADORA1
SCHEMBL27185303 0.65 F2 (0.47) NQO2KDM4EHSD17B10NCF1LMNA
SCHEMBL22011246 0.64 FGFR4 (0.31)
SCHEMBL27185312 0.64 HCAR3 (0.50) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4103257-A BLUE TO NEAR ULTRAVIOLET THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) 1978-07-25 US disclosed